4 生命科学与医疗 职位 Shanghai / Shenzhen

Responsibilities:  Execute target mining, target validation, and program initiation based on robust tumor biology and clinical insights to fulfill BeiGene drug discovery goals  Support oncology drug discovery programs, including but not limited to small molecule drugs or antibody-drug conjugates (ADCs...

China NDA & Regulatory Support Serve as the key PV contact for China NDA-related activities. Support preparation, review, and response to NMPA/CDE safety-related questions and information requests during the NDA review process. Provide PV input to China regulatory submissions, safety documents, ri...

We are seeking an experienced scientist to drive novel target discovery through the development and application of AI Agents, bioinformatics, and biomedical data science. This role will build reusable Agent Skills, biomedical knowledge databases, and scalable analytical workflows, and will directly use these capab...

岗位职责 1. 环肽分子设计与优化 ◦ 负责环肽（cyclic peptide）先导化合物的设计、合成与构效关系（SAR）研究 ◦ 运用固相多肽合成（SPPS）及环化策略（head-to-tail、side-chain-to-side-chain、stapling等）构建环肽化合物 ◦ 基于靶标三维结构（X-ray/Cryo-EM/NMR/AlphaFold），进行环肽或小分子的结构导向药效优化（SBDD） ◦ 负责环肽的药代动力学（PK）性质优化，包括代谢稳定性、膜透过性、口服生物利用度、血浆半衰期等 2. 非天然氨基酸应用与创新技术 ◦ 将非天然氨基酸（non-natural am...